What is addiction?
A complex condition of compulsive engagement in rewarding stimuli despite negative consequences.
Core Mechanism: Physical dependence occurs when the body adapts to the presence of a drug, leading to physiological changes that cause unpleasant symptoms if use of the drug stops.
When someone is physically dependent on a substance, their body requires it to function normally. This dependence manifests through withdrawal symptoms (e.g., sweating, shaking, and nausea). Chronic drug use disrupts homeostasis, leading to the body’s adjusted baseline now requiring the drug to maintain stability.
These two concepts define how the body and brain adjust to chronic substance use.
Key factors that maintain and intensify the state of addiction:
What is addiction?
A complex condition of compulsive engagement in rewarding stimuli despite negative consequences.
What is physical dependence?
When the body adapts to a drug, causing withdrawal symptoms if use stops.
What causes withdrawal symptoms?
Physiological and psychological effects occurring when a drug is reduced or stopped.
What is psychological dependence?
Emotional and cognitive cravings or perceived needs to use a substance or behavior.
How does tolerance develop?
Through repeated drug use, the brain becomes less responsive, requiring higher doses.
Why is tolerance dangerous?
It increases overdose risk due to higher consumption needed for effect.
What is withdrawal syndrome?
Symptoms experienced after stopping or reducing drug use in physically dependent individuals.
Give an example of withdrawal symptoms from opioids.
Sweating, shaking, and nausea.
How does addiction maintain itself?
Through physical dependence, psychological dependence, tolerance, and withdrawal symptoms.
What role do environmental triggers play in addiction?
They reinforce addictive behaviors by associating cues with substance use.